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CSA-600F - 200 Popularity µg Anti-Clip Max 57% OFF Antibody Monoclonal Eac Mouse

CSA-600F - 200 µg - Anti-Clip Mouse Monoclonal Antibody - Eac

$309

CSA-600F - 200 µg - Anti-Clip Mouse Monoclonal Antibody - Eac

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Product description

CLIP (class II-associated invariant chain peptide) is an important peptide in the MHC-II antigen processing pathway, formed by the enzymatic cleavage of amino acids 81-104 from the invariant chain. During MHC-II synthesis in the ER and transport to endocytic vesicles, the antigen binding site of MHC-II is obstructed by the presence of the invariant chain. As the MHC-II complex moves through the Golgi, the invariant chain is degraded, leaving the CLIP fragment in the MHC-II peptide binding groove. CLIP is eventually displaced by the loading of antigenic peptides, followed by presentation on the APC cell surface to CD4+ T-cells. For Immunoprecipitation Recognizes human CLIP. Detects a band of ~33-35kDa by Western blot. Type: PrimaryAntigen: CLIPClonality: MonoclonalClone: Conjugation: Epitope: Host: MouseIsotype: Reactivity:

CSA-600F - 200 µg - Anti-Clip Mouse Monoclonal Antibody - Eac

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